تحميل برنامج لمشاهدة الافلام

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Specific and Structurally Non-Specific Activity

Drug activity can be classified as:-
 

(a) Structurally non-specific activity.
 

(b) Structurally specific activity.


1- Structurally non-specific activity
** It is depend on the physical properties of the drug like solubility partition coefficients and vapor pressure and not on the presence or absence of some chemical group.
 
** Substances such as alkanes, alkenes, alkynes, alcohols, amides, ethers, ketones and chlorinated hydrocarbons exhibit narcotic activity and potency of each substance is related to its partition coefficient.
 
** Structurally non-specific action results from accumulation of a drug in some vital part of a cell with lipid characteristics.
 
** The structurally non-specific drugs include general anesthetics, hypnotics together with a few bactericidal compounds and insecticides.


2- Structurally specific activity 
It is depend upon some factors such as the presence or absence of certain functional groups, intramolecular distance, and shape of the
molecules.
 
** Activity is not easily co-related with any physical property and small changes in structure often lead to changes in activity.
 
** Structurally specific activity is dependent upon the interaction of the drug with a cellular receptor.

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